|
KMID : 0043320160390121628
|
|
Archives of Pharmacal Research
2016 Volume.39 No. 12 p.1628 ~ p.1634
|
|
|
A new rearranged eudesmane sesquiterpene and bioactive sesquiterpenes from the twigs of Lindera glauca (Sieb. et Zucc.) Blume
|
|
Yu Jae-Sik
Baek Ji-Won
Park Hyun-Bong
Moon Eun-Jung
Kim Sun-Yeou
Choi Sang-Un
Kim Ki-Hyun
|
|
|
Abstract
|
|
|
|
A new rearranged eudesmane sesquiterpene, named eudeglaucone (1), and five known sesquiterpenes including (+)-faurinone (2) and four eudesmane-type sesquiterpenes (3?6), were isolated from the twigs of Lindera glauca (Sieb. et Zucc.) Blume. The structure of 1 was elucidated by a combination of extensive spectroscopic analyses, including extensive 2D NMR (1H-1H COSY, HMQC, HMBC, and NOESY) and HR-MS. Compound 1 was a relatively rare rearranged eudesmane sesquiterpene in terpenoids. All isolates were evaluated for their antiproliferative activities against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15). Compounds 3 and 6 showed significant cytotoxicity against SK-MEL-2 and HCT-15 cell lines with IC50 values ranging from 9.98 to 12.20 μM. We also investigated the anti-neuroinflammatory activities of the isolates (1?6) in the lipopolysaccharide (LPS)-stimulated murine microglia BV-2 cell line by measuring nitric oxide (NO) levels. All isolates significantly inhibited NO production with IC50 values of 3.67?26.48 μM without inducing cell toxicity.
|
|
|
KEYWORD
|
|
|
Lindera glauca, Lauraceae, Sesquiterpene, Cytotoxicity, Anti-inflammation
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|